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SDZ 224-015

CAS No. 161511-45-1

SDZ 224-015( —— )

Catalog No. M34857 CAS No. 161511-45-1

SDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1, exhibiting anti-COVID-19 and anti-inflammatory activity, and reducing carrageenan gum-induced paw edema in rats.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SDZ 224-015
  • Note
    Research use only, not for human use.
  • Brief Description
    SDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1, exhibiting anti-COVID-19 and anti-inflammatory activity, and reducing carrageenan gum-induced paw edema in rats.
  • Description
    SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM).
  • In Vitro
    ——
  • In Vivo
    SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema.SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    IL Receptor
  • Recptor
    IL Receptor | Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    161511-45-1
  • Formula Weight
    652.52
  • Molecular Formula
    C30H35Cl2N3O9
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (153.25 mM; Ultrasonic )
  • SMILES
    CCOC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)COC(=O)c1c(Cl)cccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208.?
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